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About Xaira Therapeutics

Xaira Therapeutics is an integrated biotechnology company driving advances in artificial intelligence to learn the language of life and transform how we treat disease. The company seeks to rethink the drug discovery and development process from end-to-end by bringing together leading talent across three core areas: machine learning research to better understand biology, expansive data generation to power new models, and robust therapeutic product development to treat disease. Xaira is headquartered in the San Francisco Bay Area, Seattle and London.

About the Role

We are looking for a talented and innovative Principle Scientist to join our Advanced Cell Engineering team at Xaira Therapeutics. This role involves designing and executing advanced cell engineering protocols and differentiation strategies to support our high-throughput functional genomics and drug discovery efforts. The scientist will lead the development of iPSC-based models to enable cutting-edge research in functional genomics and disease modeling collaborating with cross-functional teams to drive impactful results.

Key Responsibilities

• Design, develop, and optimize protocols for iPSC engineering, gene editing, and targeted cell differentiation to model disease states and physiological conditions.
• Lead iPSC-based pooled CRISPR screening and perturb-seq projects, ensuring high-quality experimental design, data generation, and analysis, with a focus on reproducibility and scalability.
• Conduct gene editing (e.g., CRISPR) to create custom iPSC lines, validating genotypic and phenotypic fidelity.
• Develop and implement QC protocols to assess cell quality, viability, and phenotype during iPSC maintenance, expansion, and differentiation stages.
• Troubleshoot experimental challenges and develop innovative solutions to improve efficiency and outcomes in iPSC engineering and differentiation.
• Mentor and supervise junior scientists and research associates, providing guidance on experimental techniques, data interpretation, and career development to foster technical growth and professional success.
• Collaborate closely with other scientists in functional genomics, assay development, and high-throughput screening to integrate engineered iPSC lines into various discovery workflows.
• Present findings, updates, and recommendations to project teams and senior management.

Qualifications

• PhD in Cell Biology, Molecular Biology, Bioengineering, or related field, with 8-10 years of postdoctoral or industry experience.
• Strong expertise in iPSC culture, maintenance, gene editing (e.g., CRISPR), and differentiation techniques.
• Proven experience in developing and troubleshooting iPSC differentiation protocols for various cell types.
• Familiarity with pooled CRISPR screening and/or perturb-seq.
• Hands-on experience with molecular and cell biology biology techniques, including PCR, flow cytometry, immunocytochemistry, cloning and viral transduction.
• Experience with data analysis using Python or R is a plus.
• Exceptional analytical skills, attention to detail, and a strong ability to work independently as well as collaboratively.
• Strong written and verbal communication skills, with a demonstrated ability to present scientific data effectively.

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. The base pay range for this position is expected to be $160 - $180,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.