Job Title: Principal Scientist to Director, Structural Biology

Reports To: VP, Chemistry

Location: Shanghai, China

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

In this role, you will join a motivated team of scientists contributing to pipeline projects with a focus on determining structures of drug targets in complex with molecules, to influence all stages of our drug discovery efforts. In addition, you will be involved in making innovative contributions to understand the fundamental regulatory mechanisms of drug targets by structural biology. You will work closely with teams in other functional areas and with CROs.

Structure Therapeutics is seeking a Scientist to join our drug discovery team as a key member. The ideal candidate will hold a Doctorate degree in structural biology and will be an enthusiastic contributor to our fast-paced interdisciplinary team. This team is dedicated to advancing our groundbreaking technology platform, with a focus on discovering novel lead candidates for clinical development.

The successful candidate will possess excellent communication skills, strategic thinking abilities, and scientific knowledge, with specific expertise in protein chemistry, membrane protein cryo-electron microscopy.

Responsibilities for this position include maintaining and accelerating our structure-based drug discovery through hands-on engagement in projects to ensure efficient generation of crucial structural information.

As a crucial part of our integrative platform, the successful candidate will also be responsible for analyzing, organizing, and curating primary data generated from structural biology and protein assay activities, and s(he) will be required to integrate this information with medicinal chemists, computational chemists, and biologists.

Working closely as a team member with experienced drug hunters, the Scientist will gain significant experience in the Structure Therapeutics drug discovery system. This position presents a unique opportunity for the individual to make a major contribution to the success of a well-positioned growth stage US-China biopharmaceutical company.

Job Responsibilities:

• Implement company’s structural biology efforts through close coordination with research collaborators and CROs specifically in the generation of GPCR protein and ligand complex structures.
• Facilitate utilization of purified protein assays, functional and binding assays to support medicinal chemistry SAR efforts, directed mutagenesis to support computational chemistry.
• Contribute to growing knowledge base of membrane protein chemistry and structural biology through meticulous record keeping, data entry into various LIMs systems.
• Interpretation of structural information through close interactions with medicinal chemists and biologists.

Qualifications:

Core Competencies, Knowledge and Skill Requirements

• Solid knowledge in structural biology

• Hands-on experiences for cryo-EM and/or x-ray crystallography, data processing and structure determination
• Experiences in macromolecule structure analysis

Communication & Interpersonal Skills

• Excellent verbal and written communication skills
• Fluent in reading, writing, and speaking Chinese and English

• Ability to effectively collaborate in a dynamic environment
  

Experience

• D in biological science, protein chemistry or structural biology with at least 5 years of industry experience
• Experience in designing and implementing experiments in a logical and consistent manner
• Strong desire to develop skills in a multidisciplinary environment
• Highly motivated, results driven individual with excellent organizational, interpersonal and communication skills and willingness to work in geographically distributed teams
• Ability to collaborate. Work cross functionally with other groups, CROs, and academic labs is essential to this role.
• Proactive, hands-on style, possessing strong individual drive.

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, ongoing performance-based equity and various benefits offerings.