Job Title: Scientist or Senior Scientist, in vitro Biology

Reports To: Principal Scientist, Biology

Location: Shanghai, China

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

We are seeking a highly motivated and experienced vitro biologist. This position plays a critical role in the execution and development of cellular and biochemical assays to support drug discovery programs. The successful candidate will independently design, perform, troubleshoot, and optimize vitro assays — particularly those related to GPCRs and metabolic diseases — and oversee CRO’s work for smooth progress, to generate high-quality, reproducible data in support of project goals.

Job Responsibilities:

• Develop, optimize, and validate novel cell-based or ex vivo assays aligned with project needs.
• Communicate with CROs for new experiment design, assay optimization, routine screen maintenance and data QC, to ensure stable data readout for project progress.
• Troubleshoot and resolve technical issues with assay performance and data quality in a timely manner with flexibility.
• Apply scientific insights to improve assay design and drive innovation in assay platforms.
• Evaluate and implement new technologies or methods relevant to GPCRs and metabolic diseases.
• Execute in vitro biology experiments with high quality and scientific rigor in a timely manner if project needs.
• Maintain accurate and thorough external and internal laboratory records in accordance with best practices.
• Collaborate effectively with cross-functional project teams and contribute to project strategy.
  

Qualifications:

Education & Experience

• Ph.D. in Cell Biology, Molecular Biology, Pharmacology, or a related field.
• A minimum of 3 years of hands-on experience in in vitro assay development and execution; CRO experience is a plus.
• Proven expertise in GPCR-related assays and/or assays relevant to metabolic disease biology.

Technical Skills & Competencies

• Extensive experience with cell culture (including primary cells), HTRF, luciferase-based assays, qPCR, Western blotting, FACS, imaging-based assays, and other standard molecular biology/biochemical techniques.
• Demonstrated ability to troubleshoot complex assay issues and optimize experimental protocols.
• Strong organizational skills, attention to detail, and commitment to data integrity.
• Proficiency with scientific software and tools (e.g., GraphPad Prism, MS Office Suite).
• Self-driven, proactive, and able to work both independently and collaboratively in a team-oriented environment.

Communication

• Excellent verbal and written communication skills.

Strong ability to document work clearly and communicate scientific data effectively across internal and external teams.

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, ongoing performance-based equity and various benefits offerings.

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We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.

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