Job Title: Senior Scientist/Principal Scientist, in vitro Biology

Reports To: Director, Biology

Location: Shanghai, China

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

We are seeking a Senior Scientist / Principal Scientist to lead and advance in vitro receptor pharmacology efforts across our internal drug discovery programs. This role will serve as a scientific owner for in vitro pharmacology capabilities, supporting GPCR-focused programs in metabolic diseases, including obesity and liver-related indications.

The successful candidate will bring deep expertise in either receptor pharmacology and/or metabolic disease biology, with the ability and interest to bridge disciplines through close collaboration with cross-functional teams and external partners.

Job Responsibilities:

• Provide scientific leadership and ownership of in vitro receptor pharmacology strategies to support GPCR-driven drug discovery programs.
• Design, develop, and optimize receptor binding assays, binding kinetics assays, and receptor de-sensitization assays to enable compound profiling and decision-making.
• Establish and evolve in vitro pharmacology and biology competencies aligned with program platform needs.
• Drive a strong understanding of target and disease biology, and integrate biological insights into assay design and data interpretation.
• Generate, review, and interpret high-quality pharmacology data from internal studies and CRO partners, influencing project go/no-go and prioritization decisions.
• Lead and manage CRO collaborations, ensuring scientific rigor, data quality, and timely delivery.
• Communicate scientific findings clearly and effectively in internal project teams and at external scientific meetings.

Qualifications:

Required

• Ph.D. in pharmacology, biochemistry, biophysics, or a related field, with 2-year post-doctoral and/or industry research experience.
• Demonstrated depth in at least one of the following areas:
  • Receptor pharmacology, preferably with class B GPCR targets
  • Metabolic disease biology, including obesity and/or liver-related diseases
• Strong experience in designing, executing, and interpreting in vitro pharmacology assays or disease-relevant biological assays.
• Proven ability to take scientific ownership, work independently, and drive projects in a cross-functional environment.
• Excellent written and verbal communication skills.

Preferred

• Hands-on experience with receptor binding assays and/or binding kinetics methodologies (e.g., TR-FRET, FP, radioligand binding assays, MST/SpS, SPR, sc-IC).
• Prior experience supporting GPCR-focused drug discovery programs.
• Experience managing CROs and external scientific collaborations.
• Prior experience in a fast-paced biotech or pharmaceutical R&D environment.

Travel Required:

Occasional domestic or international travel may be required for scientific conferences or business needs.

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, ongoing performance-based equity and various benefits offerings.

Notice to Recruiters/Staffing Agencies

Recruiters and staffing agencies should not contact Structure Therapeutics through this page. All recruitment vendors (search firms, recruitment agencies, and staffing companies) are prohibited from contacting our hiring manager(s), executive team members, or employees.

We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.

Structure Therapeutics’ receipt or acceptance of an unsolicited resume submitted by a vendor organization to this website or employee does not constitute an actual or implied contract between Structure Therapeutics and such organization and will be considered unsolicited and Structure Therapeutics will not be responsible for related fees.

Fraud Alert

To all candidates: your personal information and online safety are a top priority for us. At Structure Therapeutics, direct candidates to apply through our official career page at BambooHR.

Recruiters will always contact you using the domain of Structuretx.com. We will never request payments, ask for financial account information or sensitive information like social security numbers. If you are unsure if a message is from Structure Therapeutics, please email human resources StructureHR@structuretx.com.