Job Title: Scientist/Senior Scientist of Structural Biology

Reports To: Principal Scientist, Structural Biology

Location: Shanghai, China

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

Structure Therapeutics is recruiting a Scientist I position to become a key member of Shanghai drug discovery team. S(he) will have Doctorate degree in protein chemistry or structural biology and will be an enthusiastic contributor to our fast-paced interdisciplinary team advancing our groundbreaking technology platform applied to discovery of novel lead candidates for clinical development. S(he) will be responsible for maintaining and accelerating our structure-based drug discovery platform through direct interactions with collaborators and contract research organizations and hands-on engagement in projects to ensure efficient generation of key structural information. The individual will work closely as a team member with experienced medicinal chemistry and biology drug hunters and gain significant experience in the Structure Therapeutics drug discovery system.

As a key component in our integrative platform s(he) will also be responsible for analysis, organization and curation of primary data generated from structural biology and protein assay activities and integration of that information with medicinal chemists and biologists. In addition to world class technical capabilities the position will require the ability to communicate with cross-functional team members both locally and globally.

The successful candidate will have strong communication skills, strategic thinking, and scientific knowledge with expertise in protein chemistry, membrane protein crystallography and cryo-electron microscopy. This is a unique opportunity to be a major contributor to the success of a well-positioned growth stage US-China biopharmaceutical company.

Job Responsibilities:

• Implement company’s structural biology efforts through close coordination with research collaborators and CROs specifically in the generation of GPCR protein and ligand complex structures.
• Facilitate utilization of purified protein assays, functional and binding assays to support medicinal chemistry SAR efforts, directed mutagenesis to support computational chemistry.
• Contribute to growing knowledge base of membrane protein chemistry and structural biology through meticulous record keeping, data entry into various LIMs systems.
• Interpretation of structural information through close interactions with medicinal chemistry, CADD and biology team members.

Qualifications:

• D in biological science, protein chemistry or structural biology
• Experience in designing and implementing experiments in a logical and consistent manner.
• Strong desire to develop skills in a multidisciplinary environment.
• Highly motivated, results driven individual with excellent organizational, interpersonal and communication skills and willingness to work in geographically distributed teams.
• Ability to work cross functionally with CROs, academic labs and cross functional groups is essential to this role.
• Proactive, hands-on style, possessing strong motivation and individual drive.

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, ongoing performance-based equity and various benefits offerings.

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