About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:
The Director, Pharmacometrics will work with cross-functional stakeholders across Structure Therapeutics, supporting discovery, preclinical development, and clinical development of pipeline molecules. The position will contribute to translational approaches to inform clinical development and define the optimal dose, route, and regimen. The position will lead pharmacometrics deliverables supporting regulatory submissions and health authority interactions, and will communicate results and key messages to internal teams and, as appropriate, external partners. The position will report to the Executive Director, Head of Pharmacometrics.

Job Responsibilities:
• Support and help advance model-informed drug development (MIDD) across discovery and development programs.

• Represent Pharmacometrics on cross-functional teams, providing quantitative input to strategy, dose selection, and trial design; influence decisions through data-driven recommendations.

• Plan, execute, and document pharmacometrics analyses (PopPK/PKPD/exposure–response), including models, simulations, and reports.

• Develop and maintain Shiny-based applications to enable data visualization and model-based simulation workflows, with potential integration of AI/ML-enabled features as appropriate.

• Coordinate and oversee external vendors/consultants and review deliverables for quality and timeliness.

• Contribute to pharmacometrics elements of regulatory submissions and health authority responses, with guidance from function leadership.

• Support functional process improvements (e.g., templates, workflows, and modeling infrastructure) and other needs (e.g., due diligence) as assigned.

Core Competencies, Knowledge, and Skill Requirements:
• Strong cross-functional collaboration and communication skills (written and verbal), able to convey quantitative results clearly.

• Strong data programming and analytical skills to deliver high-quality ad hoc PK/PD and pharmacometrics analyses.

• Working knowledge of relevant regulatory expectations for pharmacometrics/clinical pharmacology deliverables.

• Strong project execution skills: prioritization, quality, and timeline management in a fast-paced environment.

• Experience managing external partners and operating with appropriate autonomy and escalation.

Qualifications:
Education:
• Advanced degree (PhD, PharmD, MS) in Engineering, Mathematics, Statistics, Pharmaceutical Sciences, or a related field.

Experience:
• 7+ years of drug development experience in biotech/pharma (or equivalent combination of industry and relevant consulting experience).

• Demonstrated hands-on experience with commonly applied pharmacometric methodologies (e.g., PopPK, PKPD, exposure–response, MBMA/statistical modeling).

Proficiency with pharmacometrics and data analysis tools such as NONMEM, R, and one or more of Monolix, Phoenix/WinNonlin, Matlab, SAS (as appropriate for role).

• Experience contributing to clinical pharmacology/pharmacometrics deliverables that support regulatory submissions and/or health authority interactions.

• Experience with dataset creation and data assembly/review/visualization in support of modeling deliverables.

• Experience applying AI/ML in drug development preferred.

• Experience supporting small-molecule development preferred; cardiometabolic experience (e.g., T2D/obesity) preferred; PBPK experience using platforms such as Simcyp and/or GastroPlus preferred.

Travel Required:
• Approximately 10–15%, including scientific conferences and periodic travel to company sites as needed (potential travel to China and periodic time in the SSF, CA office).

Structure Therapeutics Inc. is an Equal-Opportunity Employer.
Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $225K-$290K. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance-based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.

Notice to Recruiters/Staffing Agencies

Recruiters and staffing agencies should not contact Structure Therapeutics through this page. All recruitment vendors (search firms, recruitment agencies, and staffing companies) are prohibited from contacting our hiring manager(s), executive team members, or employees.

We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.

Structure Therapeutics’ receipt or acceptance of an unsolicited resume submitted by a vendor organization to this website or employee does not constitute an actual or implied contract between Structure Therapeutics and such organization and will be considered unsolicited and Structure Therapeutics will not be responsible for related fees.

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