Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company has completed an initial public offering (IPO) in February of 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary

Structure Therapeutics is seeking a (Senior) Scientist to join our Molecular Interaction team in Shanghai. This role supports in vitro pharmacology and biophysics efforts to advance our internal drug discovery programs, with a primary focus on GPCR targets. Responsibilities include assay development, CRO management, and cross-functional collaboration, all contributing to our mission of making medicine more accessible.

KEY RESPONSIBILITIES

• Develop and optimize binding and functional assays.
• Manage and coordinate CROs to deliver reliable, well-documented results.
• Generate high-quality data on binding or function kinetics and affinity.
• Scout and integrate new technologies, vendors, and advisors into the platform.
• Present data in project team discussions and represent the function.
• Collaborate in a matrixed team to support discovery pipelines.

QUALIFICATIONS:

• Ph.D. in pharmacology, biochemistry, biophysics, or related field (or M.S. with significant experience).
• Hands-on expertise in biochemical/biophysical assays (e.g. TR-FRET, FP, RLA, MST/SpS, SPRm, sc-IC).
• Experience managing CROs and ensuring data quality.
• Strong communication skills and team-oriented mindset.
• Willingness to relocate to or work in Shanghai.
  

Nice to Have

• Experience in Pharma, Biotech, or CRO setting.
• Understanding of GPCR pharmacology and receptor–ligand kinetics.
• Familiarity with image-based assays and high-content analysis.
• Exposure to bioinformatics or AI/ML applied to biological data