Executive Medical Director
Structure Therapeutics
Structure Therapeutics develops life changing medicines for patients using advanced structure based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.
Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company has completed an initial public offering (IPO) in February of 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.
POSITION SUMMARY
The Executive Medical Director at Structure Therapeutics will provide medical leadership on clinical drug development of the assigned compound(s), including creating a clinical development strategy and plan, and all related activities. These activities may include, but are not limited to, study design and conduct, participation in key regulatory interactions as medical expert (IND and NDA), and being the medical lead to communicate with health authorities and medical societies during the drug development process.
ESSENTIAL DUTIES AND RESPONSIBILITIES
- Maintain current scientific knowledge in relevant therapeutic areas and therapeutic mechanisms through review of scientific literature and attendance at relevant scientific meetings
- Lead development of global clinical strategy and clinical development plan for assigned projects
- Provide medical leadership for the effective conduct of clinical trials, including:
- Collaboration with other functional areas to design clinical development plans and study protocols
- Monitor and review medical data for clinical trials and represents the sponsor in Safety Review Committees
- Engage with clinical investigators and study site personnel
- Analyze, present, and interpret data from clinical studies
- Partner with Regulatory Affairs to ensure effective collaboration with global Health Authorities, including:
- Preparation of clinical documents, or clinical sections of documents, as required
- Participation in updating key documentation (IB, DSUR, etc.)
- Represent Structure Tx in external engagement-related activities:
- Interact with external experts from health authorities and/or academic institutions (e.g., Scientific Advisory Committee, Key Opinion Leaders) as appropriate
- Manage interactions with investigators to address scientific questions
- Publish data in appropriate peer-reviewed platforms with abstract/poster, presentations, and manuscripts
- Collaborate actively with cross functional teams, such as Pharmacovigilance, Regulatory Affairs, Clinical Operations, Data Management, Biostatistics etc.
- Evaluate opportunities and plans on assigned molecules for the development of new indications
- Participate and support the research, in/out licensing of new targets or drugs in related areas led by business development and/or preclinical research team
- Other duties as assigned
CORE COMPETENCIES, KNOWLEDGE AND SKILL REQUUIREMENTS
- Deep knowledge of study design, protocol development and study conduct
- Excellent written and oral communication skills in the negotiation, presentation, and authoring process with relevant cross function team, medical experts, as well as regulatory reviewers
- Sufficient knowledge of business processes, regulatory, and compliance related to drug development
- Excellent verbal and written communication skills
- Ability to effectively collaborate in a dynamic environment
- Competency in decision making, influencing, and execution in a changing business environment
- Comfortable with uncertainties through excellent risk management skill
REQUIREMENTS
Education
- Medical degree (MD or equivalent) with clinical experience in metabolic or related areas preferred
Experience
- 5-8+ years of experience in clinical drug development in the pharmaceuticals/biotech industry, including designing and implementation of clinical projects in early/late stage
- Experience in preparation and submission of clinical trial and/or new drug applications
- Managerial experience of a medical team preferred
Travel - 20%
The target salary range for this full-time role is $300,000 to $350,000 + bonus + equity + benefits. Structure Therapeutics determines salary ranges based on level and scope of responsibilities, as well as location. Individual pay is further determined by additional factors, including relevant experience, specific job skills, education and training. More details about the specific salary range for your location will be discussed with you during the hiring process by the StructureTx Talent Acquisition Team.