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Downstream Process Development and Manufacturing Scientist

Singular Genomics

Singular Genomics

San Diego, CA, USA
Posted on Tuesday, February 6, 2024


Singular Genomics is inventing at the forefront of genomics, one of the world’s fastest-growing industries. The commercially available G4® Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In addition, the company is currently developing the G4X™ Spatial Sequencer, an upgrade to the G4, which will leverage Singular’s proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context. Singular Genomics’ mission is to empower researchers and clinicians to advance science and medicine.

We foster a culture of creativity and technical excellence, both catalysts for innovation. We celebrate diversity, emphasize collaboration and, as we rapidly mature, we are constantly looking at ways we can do better for our people.

Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub. Our Manufacturing facility is in Sorrento Valley. This role reports to our Torrey Pines location.

The Enzyme Manufacturing and Process Development team develops and makes enzymes used in Singular Genomics proprietary chemistries. As a Downstream Process Development and Manufacturing Scientist, you will be responsible for the technology transfer and production of enzymes.

What you will do (responsibilities):

  • Collaborate closely with R&D to facilitate technology transfer of expression and purification procedures to manufacturing.
  • Perform manufacturing protein expressions (bioreactor) and purifications (Akta systems) adhering to established protocols and document all process data clearly in batch records and PowerPoint presentations.
  • Continuously evaluate and improve current manufacturing process and design. Focusing on scale up and optimizing the process by shortening, streamlining, improving robustness, or reducing labor and cost of the process.
  • Author and review comprehensive process documentation, including standard operating procedures (SOPs), work instructions (WI) and batch records (BR).
  • Provide support, guidance and mentorship to junior scientists and associates. Share knowledge and expertise to support their professional growth.
  • Troubleshoot any technical challenges and propose innovative solutions for process improvement.
  • Foster good work relationships with cross-functional teams, including R&D, reagents manufacturing team and quality control team.
  • Stay abreast of the latest downstream processing technologies and techniques advancements. Evaluate, recommend, and implement new methods, equipment, or technologies to enhance processes.


  • Degree in Life Sciences with relevant hands-on industry experience: B.S. 5 years, M.Sc. 3 years, PhD 1 year.
  • Extensive protein expression and purification experience required.
  • Proficiency in operating bioreactors and Akta purification systems highly preferred.
  • Experience in drafting and revising procedures in an ISO:13485 quality environment.
  • Experience in cGMP and GLP a plus.

The estimated base salary range for this role based in the United States of America is: $79,500 - $121,400. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Should the level of the role change during the hiring process, the applicable salary range may be updated accordingly. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package.

Singular Genomics is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Singular Genomics is committed to working with and providing reasonable accommodations to job applicants with physical or mental disabilities. Applicants with a disability who require a reasonable accommodation for any part of the application or hiring process can provide their name and contact information to our Accommodations team at Your request will be responded to as soon as possible.

Please note: Singular Genomics does not accept agency resumes and is not responsible for any fees related to unsolicited resumes. Please do not forward resumes to Singular Genomics employees.