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Director, Medicinal Chemistry Scale Up

Semma Therapeutics

Semma Therapeutics

San Diego, CA, USA
Posted on Wednesday, May 22, 2024

Job Description

The Medicinal Chemistry Scale Up group is strategically placed between the Medicinal and Process Chemistry groups to facilitate the progression of candidate molecules towards clinical development. The Director, Medicinal Chemistry Scale Up, is responsible for outstanding cross-functional collaboration enabling compound advancement through synthetic chemistry innovation. These cross-functional contributions extend from the identification of lead candidates with Medicinal Chemistry teams to providing API for pre-clinical safety studies to route design supporting early clinical development in conjunction with Process Chemistry stakeholders. The successful candidate will be responsible for inspiring the highest level of excellence in modern synthetic chemistry methods as well as defining the future vision for accelerating the development of breakthrough drug candidates to clinical studies. This position will be responsible for supporting the growth and development of group members both personally and scientifically within and beyond the Chemistry function. The successful candidate will have an outstanding record of project impacts potentially including acceleration of drug candidate progression, presentations, patents, and publications. This is an onsite position at our San Diego research site.

Key Duties & Responsibilities

  • Sets Medicinal Chemistry Scale Up strategic direction to enable API route development to support project goals.
  • Encourages and enables cross-functional collaboration with Medicinal and Process Chemistry, Analytical Chemistry and Development, Formulation, and Drug Metabolism to support API deliveries for pre-clinical evaluation
  • Provides mentorship supporting scientific and personal development, motivates personnel, and resolves conflicts utilizing an individualized approach
  • Ensures personnel goal setting is effectively linked to corporate and department goals
  • Adapts personnel deployment to changing priorities to ensure key project goals are accomplished
  • Provides strategic direction supporting planning and execution of activities provided by CRO partners and/or external scientific collaborations
  • Maintains a standard of excellence for interpretation of all laboratory records, electronic database entries, internal reports, patents and external communications
  • Communicates company objectives and availability of resources to the group and to project team(s) in a clear and timely manner
  • Leads preparation of lucid scientific reports for all other branches and levels of the organization and its collaborators, presents expertly when called upon, and develops abilities of others in this role
  • Contributes to synthetic chemistry innovation in the laboratory when necessary

    Required Experience / Required Knowledge/Skills

    • Experience integrating the activities of distinct functional groups across multiple projects
    • Experience identifying and establishing productive new research initiatives/directions as they apply to a future state of laboratory technologies
    • Experienced mentor who effectively infuses confidence and team commitment
    • Exhibits a record of excellent operational and ethical standards and team improvement
    • Possesses knowledge of drug discovery and development including requirements for compound advancement through GLP, GMP, CMC, Analytical Development, and formulation science.
    • Experience resolving important organizational problems through innovation and collaboration
    • Experience with reaction analytics and high-throughput experimentation

    Required Education Level

    • Ph.D. (or equivalent degree) in chemistry or related science and 10+ years of relevant postdoctoral employment experience, or
    • Masters Degree (or equivalent degree) in chemistry or related science and 12+ years of relevant employment experience, or
    • Bachelors Degree (or equivalent degree) in chemistry or related science and 15+ years of relevant employment experience

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    Pay Range:

    $188,000 - $282,000

    Disclosure Statement:

    The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

    At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

    Company Information

    Vertex is a global biotechnology company that invests in scientific innovation.

    Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

    Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com