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Analytical Development Scientist - Cell & Gene Therapy

Semma Therapeutics

Semma Therapeutics

Boston, MA, USA
Posted on Thursday, May 16, 2024

Job Description

General Summary:

  • Vertex pharmaceuticals is seeking a research scientist to join the analytical development, cell and gene therapy team. This position is expected to serve as a key contributor in expanding our mass spectrometry characterization capabilities in proteomics for supporting cell and gene therapy program development. Extensive hands-on experience in liquid chromatography-mass spectrometry and proteomics is required. The individual in this role will collaborate closely with research, process development, manufacturing, regulatory, and quality to develop and innovate Vertex next generation Cell and Gene Therapy products.

Key Duties and Responsibilities:

  • Provide hands-on support for mass spectrometry-based proteomics characterization and perform biological pathway analysis.
  • Conduct proteomics experiments on different cell types (intracellular and cell surface) including but not limited to stem cells, differentiated cells, single cell.
  • Use state-of-art LC-MS platforms (Orbitrap, Q-ToF, QQQ, etc.) coupled with different front-end chromatographic separation techniques (reverse phase, HILIC, ion exchange, size exclusion, etc.) to advance Vertex’s pipeline molecules.
  • Provide expertise in experimental design, data analysis, assay trouble shooting, technical report writing, and presentations.
  • Author analytical method, qualification, and validation reports.
  • Maintain proper documentations of experimental results and data interpretations.
  • Ensure data quality and maintain data integrity of analytical results to support decision making.
  • Collaborate with research and process development teams to develop fit for purpose analytical characterization methods for target optimization, product characterization and product investigations.

Knowledge and Skills:

  • Strong hands-on experience on LC-MS based proteomics analysis and Orbitrap mass spectrometers is required.
  • Strong hands-on experience with advanced proteomics sample preparation techniques for protein isolation from cells, sub-cellular fractionation, immuno- or chemical affinity purification is required.
  • Strong hands-on experience with label free and TMT based multiplex quantification is required.
  • Experience with multi-omics and statistical analysis poises additional value.
  • Demonstrated capabilities to independently digest and formulate experimental conclusions by referencing orthogonal analytical results.
  • Ability to use information gained from experiments to inform method and program decisions.
  • Skilled in efficient study design and demonstrated expertise in writing SOPs, analytical protocols and reports.
  • Ability to multi-task as necessary, managing competing priorities, and advancing multiple projects within required timelines.
  • Demonstrated ability to work cross-functionally to improve communication, strong track record in cross-team collaboration.
  • Strong oral & written communication skills.

Education and Experience:

  • Typically requires the following, or the equivalent combination of education and experience: PhD (0-2 years), or Master's (4+ years), or Bachelor's (6+ years) relevant experience in biopharmaceutical industry.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.