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Intern Data and Computational Sciences

Semma Therapeutics

Semma Therapeutics

Boston, MA, USA
Posted on Tuesday, November 14, 2023

Job Description

The Vertex Internship Program offers students the opportunity to learn about the pharmaceutical industry from a hands-on perspective. You will be working closely with and learning from some of the brightest people in the industry. When you join our internship program you should not be surprised to see that our environment is one that is innovative and team oriented, where collaboration is not just a word, and "we are relentless" is in everything we do. Students can expect to be challenged by their project plan, connect with other interns, and feel valued by the Vertex community. Not only will interns learn about their day-to-day tasks through their specific work assignments, but they will interact and have exposure to our organizational leaders and their teams.

Job Summary:

We are seeking a graduate student to join Vertex for an internship experience during summer 2024 in the Data and Computational Sciences department. We are looking for an exceptional candidate to assist with enhancing our current biological target prediction capabilities. The summer intern project will focus on evaluating target prediction machine learning models in the public domain as well as building target prediction models using Vertex data. No prior experience working in industry is required.

Key Responsibilities:

  • The candidate will be expected to review the literature on biological target prediction of small molecules

  • The candidate is expected to implement target prediction models from the public domain

  • Benchmark andd re-build best performing models using Vertex data

  • Following guidance from their mentor, the candidate must have the ability to work independently and as part of a team

  • The candidate must be proactive in engaging for support and seeking guidance when needed

  • The candidate will be required to regularly present their progress in formal and informal settings to colleagues

The primary deliverable will be a Python implementation of biological target prediction models for small molecules that incorporates public data (ie, ChEMBL) as well as Vertex proprietary data. Additionally, a summary report of describing the implementation and benchmark results will be expected. If time permits, a subsequent deliverable will be to integrate this into the global Vertex predictive modeling infrastructure.


  • Master’s Degree (or in progress), or Ph.D. (or in progress) in Machine Learning, Statistics, Cheminformatics, or a related field with some experience in the use or development of computational methods

  • Background machine learning and/or statistics

  • Strong proficiency in Python

  • Proven technical proficiency and demonstrated skill in planning and interpreting analytical work

  • Effective communicator (written and verbal), especially within area(s) of expertise

  • Experience with applying computational methods and/or cheminformatics/bioinformatics tools to large-scale data

  • Exposure to basic statistical and/or machine learning methods

  • Experience with databases and chemogenomics data.

  • Awareness of software design principles

  • Legally authorized to work in the United States

  • Candidate must be enrolled in an advanced degree program if graduating Spring 2024

Program Dates: May - August 2024, Full Time

This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at