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Process Engineer I, Cell Therapy Process Development

Sana Biotechnology

Sana Biotechnology

Seattle, WA, USA
Posted on Thursday, June 13, 2024

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. As a Process Engineer I, you will report to the Director of Cell Therapy Process Development to support the development of novel allogeneic chimeric antigen receptor T (CAR T) cell manufacturing processes. You will lead the design of multiple unit operations, such as T cell culture and viral transduction, participate in the evaluation of novel technologies, support end-to-end process development studies, and facilitate tech transfers to manufacturing. You will collaborate with teams across Sana sites including Manufacturing Sciences & Technology (MSAT), Analytical Development, and Research.

What you’ll do

  • Design and execute small- and large-scale cell therapy experiments independently and in a team environment
  • Document all experimental work in an electronic lab notebook
  • Analyze data, present conclusions, and propose process design recommendations to diverse scientific and technical teams
  • Drafts technical documents including development reports, operating procedures, risk assessments, and batch records

What we’re looking for

  • B.S. in Chemical, Biological, or Biomedical Engineering plus 4 years of experience, or M.S. plus 1-2 years, or equivalent combination of education and work experience
  • >1 year of experience with mammalian cell culture, with excellent aseptic cell culture technique
  • You can design experiments using the scientific method and hypothesis testing
  • You can critically analyze data, summarize and communicate findings, and write technical documents
  • You can work independently and as part of a small team
  • You are familiar with basic concepts of immunology, as it applies to CAR-T cell therapy

What will separate you from the crowd

  • You contributed to the design of a clinical cell therapy manufacturing process, with experience with one or more of the following unit operations:
    • Primary T cell isolation and culture
    • Viral and non-viral transduction and gene editing
    • Cell washing, harvesting, and cryopreservation
  • You understand and have applied statistical Design-of-Experiments (DoE)
  • You participated in tech transfers to a GMP manufacturing site
  • You are familiar with flow cytometry and/or molecular assay techniques and analysis
  • You are a great scientific communicator

What you should know

  • Working safely in-person on a predictable and regular in-person basis is an essential job function for this position, and Sana requires that all individuals working in-person by fully vaccinated against COVID-19, including receipt of a vaccine booster shot if recommended by the CDC
  • This role includes handling of human blood products from healthy donors
  • Occasional after-hours and weekend work is required
  • Approximately 50% of your time is spent in a laboratory environment
  • 5-10% domestic travel is expected
  • The base pay range for this position at commencement of employment is expected to be between $100,000 and $125,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience

How we work together for patients

  • Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
  • Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
  • Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution

Get to know us

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. For benefit eligible employees, we cover 100% of the cost for employee health coverage and offer generous time-off (various paid time off benefits, such as holidays, vacation, sick time, and parental leave), short- and long-term disability, employer paid basic life insurance, additional voluntary life insurance protection, financial wellness programs including financial planning resources, a 401(k) Plan with an immediately vested employer match, Tuition Reimbursement and Student Loan Repayment, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually. For more details on our benefits, visit Sana’s Benefits Portal.

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.