Spring 2026 Co-op: Lung Biology
Prime Medicine
Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.
Co-op Assignment Overview
Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in cellular-based studies to join the Lung Biology team. The candidate will be involved in supporting critical efforts in developing prime editing therapies for Cystic Fibrosis patients. This role will focus on supporting preclinical and in vitro studies with an emphasis on flow cytometry, tissue processing, and advanced cell culture systems such as air–liquid interface (ALI) cultures. The successful candidate will thrive in a fast-paced research program and will enjoy working with colleagues within and across teams from multi-disciplinary backgrounds.
Primary Responsibilities:
- Keen interest in learning and performing the downstream analysis of in vivo studies, including tissue sample preparation, in vitro assays (PCR and Next-gen sequencing) and data analysis
- Set up air–liquid cultures of human bronchial epithelial cells and maintain them throughout the experimental period
- Plan and execute in vitro assays to evaluate gene editing activity in relevant primary cell models
- Follow protocols, standard operating procedures, execute assigned tasks and maintain ELN. Share responsibility in lab reagent inventory and maintaining equipment.
- Work and collaborate cross-functionally with colleagues. Collect, analyze and present data in team meetings.
Qualifications:
- Bachelors/Masters candidate in Biology-related major
- Direct experience performing routine wet lab procedures and experiments
- Hands on experience with sterile techniques and culturing of mammalian cell culture including primary cells
- Experience with tissue sample preparation and immunostaining assays (flow cytometry, FACS, ICC/IHC) is a plus
Preferred Qualifications:
- Flow cytometry/FACS experience, including sample preparation and data analysis
- In vitro molecular assays such as PCR/RT-qPCR
- Gene editing technologies and viral and/or non-viral delivery
What We Offer:
- A cutting-edge team open to mentorship and networking.
- Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
- Participation in regular seminars with industry experts.
- Full participation in employee activities including learning and development offerings, social activities, etc.
NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.