Spring 2026 Co-op: In-Process Analytics
Prime Medicine
Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.
Co-op Assignment Overview
Prime Medicine is seeking a Spring 2026 co-op with interest in large RNA molecule in-process analytics and purification to join the Chemistry team. The candidate will be involved in routine laboratory activities, including recording and taking UV absorbance measurements with NanoDrop, supporting purification, sample analysis by UPLC & mass spectrometer (MS), and endotoxin testing of synthetic guide RNA. The candidate will learn a variety of in-process analytical techniques, gain proficiency in oligonucleotide characterization, support data generation and documentation, and present results at weekly team meetings. We welcome curious problem solvers who enjoy collaborative projects and are passionate about developing gene-editing technologies to improve human health and well-being.
Key Responsibilities:
- Support characterization and purification of Prime’s long guide RNA (gRNA) using various laboratory techniques (e.g., ÄKTA purifier, UPLC, LC-MS, NanoDrop, endotoxin assays)
- Integrate chromatograms for gRNA crude, fraction, and final samples using Prime’s SOPs to quantify full-length product purity and tabulate the data in the team’s electronic lab notebook
- Learn & contribute to mass analysis of gRNA to identify molecular weight of the full-length product and related impurities
- Assist senior scientists with buffer preparation, instrument maintenance, and development of up-to-date analytical methods to help increase in-process analytical capacity
- Oversee stock of critical reagents for buffer preparation to support purification and analytics
- Coordinate with scientists to manage inventory of the final released materials
Required Qualifications:
- B.S. or M.S. candidate in Chemistry, Biochemistry, or related subjects; basic knowledge of organic chemistry preferred
- Prior completion of general chemistry and lab courses
- Excellent written and oral communication skills, strong organizational skills, ability to multi-task, and capacity to work independently or as part of a team
- A passion for learning and contributing across multiple facets of a program
Preferred Qualifications:
- Relevant internship/Co-op experience
- Completion of analytical chemistry lecture and lab courses
- Familiarity working in a chemistry laboratory and experience with instrumentation such as HPLC, LC-MS, NanoDrop, and ÄKTA Pure
What We Offer:
- A cutting-edge team open to mentorship and networking.
- Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
- Participation in regular seminars with industry experts.
- Full participation in employee activities including learning and development offerings, social activities, etc.
NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.