Fall 2025 Co-op: Liver Disease Biology
Prime Medicine
Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.
Co-op Assignment Overview
Prime Medicine is seeking a co-op for the Fall 2025 semester with experience in molecular and cell biology to join the Liver Biology team. This position offers an exciting opportunity to contribute to the identification and validation of potential curative gene-editing approaches for devastating liver diseases. The selected candidate will play a role in designing pegRNAs, delivering them to cell models, assessing editing efficiency using next-generation sequencing (NGS), and conducting cell-based assays. In this position, the co-op will gain in-depth experience with cutting-edge molecular and cell biology techniques as well as further develop data analysis and critical thinking skills all while playing an active role in contributing to the drug development process. The position will leverage close collaboration with the Computational Biology and Medicinal Chemistry teams. The ideal candidate is highly motivated, enjoys working within a collaborative team, and is passionate about developing gene editing therapies.
Primary Responsibilities:
- Designing pegRNAs and measuring their activity in multiple cell models
- Aseptic cell culture
- Transfection of mammalian cells using multiple delivery modalities (e.g. lipofection and LNP)
- Preparing gDNA samples for NGS analysis (extraction, PCR, and Illumina library preparation)
- Analysis of NGS data
- Data analysis and interpretation as well as presentations to the team
Qualifications:
- B.S. candidate in Molecular and Cell Biology, Biochemistry, or related field
- Basic knowledge of molecular biology, biochemistry, and cell biology
- Experience with basic molecular biology techniques (DNA extraction, PCR, etc.)
- Experience with mammalian cell culture
- Excellent troubleshooting, critical thinking, and communication skills
- Ability to work in a detail-oriented and organized manner
- Capacity to work independently and cooperatively within a team
- Documentation of data in electronic laboratory notebook and ensuring compliance with company policy
Preferred Qualifications:
- Experience with Microsoft Excel and PowerPoint
- Familiarity with computational analysis
- Experience with presenting scientific techniques and data
What We Offer:
- A cutting-edge team open to mentorship and networking.
- Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
- Participation in regular seminars with industry experts.
- Full participation in employee activities including learning and development offerings, social activities, etc.
NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.