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Position Overview

We are seeking a motivated Scientist/Sr. Scientist with broad expertise in genome analysis and cellular phenotyping to join our off-target group and contribute to our understanding of Prime Editing outcomes in the context of correcting genetic diseases. In this position the candidate will work with the off-target team to develop and implement assays to evaluate genomic, chromosomal, and structural off- and on- target events associated with Prime Editing. The candidate will collaborate closely with disease programs teams and their work will inform selection of lead candidates for therapeutic programs. A successful candidate will have substantial NGS experience, exposure to gene editing, and a deep understanding of assay development. The ideal candidate will have advanced analytical skills, thrive in a fast-paced environment and be comfortable working in close collaboration with multiple teams including, disease biology, computational sciences and protein chemistry to execute the company’s off-target strategies.

Key Responsibilities:

• Develop, implement, and validate assays (including NGS assays) to measure off- and on-target consequences of Prime Editing
• Contribute Cellular phenotyping and NGS expertise as part of a team developing a suite of cell biological and genomic assays for comprehensive assessment of Prime Editing
• Collaborate on cross-functional program teams to build and apply fit-for purpose methods that facilitate tiering of hits toward selection of development candidates
• Deliver reproducible and impactful results under ambitious timelines
• Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality
• Author, review, and approve protocols, SOPs, technical documents, and reports in support of regulatory submissions

Qualifications

• PhD with substantial academic and/or industry experience including a track record of impactful contributions. BSc/MSc with 5+ years of industry experience may also be considered.
• Experience with molecular biology techniques, including NGS, DNA/RNA isolation and quantification, PCR, and sanger sequencing.
• Experience with end-to-end NGS experiments including library preparation, sequencing, and analysis for at least one common modality (eg. mRNA-seq, ChIP-seq, ATAC-seq)
• Familiarity with cell culture techniques including transfection, cell line generation, genomic DNA isolation, and RNA isolation.
• Experience analyzing genomic structure in a gene editing context and/or long read sequencing is a plus
• Experience with histological samples, biodistribution studies, or AAV analysis is a plus
• Interest and background in computational analysis or data handling is a substantial plus
• Demonstrated maturity to lead with influence, work independently, and cohesively as a self-aware team player
• Strong oral, written, and verbal communication skills and the ability to work in a highly collaborative, fast-paced environment