Companies you'll love to work for

Scientist/Senior Scientist, LNP Discovery

Prime Medicine

Prime Medicine

Cambridge, MA, USA
Posted on Thursday, January 25, 2024

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit

Position Overview

We are currently seeking a talented and motivated Scientist/Senior Scientist with a strong background in lipid nanoparticle (LNP) formulation to join our growing LNP discovery team. The candidate will be involved in designing, formulating and analyzing LNPs for the delivery of prime editors to several targets in vivo. In so doing, s/he/they will learn to rationally design lipids and formulation compositions as well as optimizing those formulations using microfluidics. LNPs will then be characterized using dynamic light scattering (DLS), zeta potential, pKa and a Ribogreen assay. Efficacy of the LNPs will then be assessed directly in vivo using flow cytometry and next-generation sequencing (NGS). The scientific mentorship style will follow a three-step process, wherein the candidate will first observe the scientist conduct the experiment, next be observed while s/he/they conducts the experiment and lastly independently carryout experiments with review from the mentor. The candidate will also have weekly meetings with the mentor(s) to review experimental data and discuss weekly plans. We are looking for curious problem solvers who enjoy working on fast-paced, exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.

Primary Responsibilities:

  • Prepare LNP formulations using microfluidics
  • Perform QC assays such as DLS and Ribogreen
  • Prepare NGS libraries for sequencing
  • Prepare samples for flow cytometry (enzymatic digestion, antibody staining, etc.)
  • Analyze, organize, and present results/data in both written and oral format


  • PhD in biomedical or chemical engineering, biochemistry or related field with at least 2+ years of experience
  • LNP formulation experience
  • Experience in NGS library is a plus
  • Excellent troubleshooting and communication skills
  • Ability to work independently and within a team

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.