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Spring 2024 Co-op: Stem Cell Biology

Prime Medicine

Prime Medicine

Cambridge, MA, USA
Posted on Saturday, September 9, 2023

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit

Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Spring 2024 semester with experience in cell biology to join the Stem Cell Biology team. The candidate would work as a part of a team focused on developing iPSC-derived neuronal cell types to interrogate the effect of prime editing on gene restoration and protein function in Huntington’s disease (HD). This primary responsibility of this role will be to contribute to the development of in vitro differentiation protocols, to the validation of neuronal cell types, and to the establishment of phenotypic screening assays.

Primary Responsibilities:

  • Maintenance, QC characterization, and banking of human iPSC cell lines (hiPSC).
  • Differentiation of patient-derived iPSC cells into neuronal cell lineages and the characterization of differentiated cells.
  • Contribute to the establishment and optimization of differentiation protocols and phenotypic screening bioassays.
  • Apply/optimize prime editing to correct disease-causing mutations in iPSC-derived progeny.
  • Assist with general lab management and organizational duties such as preparing/organizing essential lab stocks and working solutions.
  • Data analysis, interpretation, and presentations within the team


  • B.S. candidate in Cell & Molecular Biology or related majors.
  • Basic knowledge of cell and molecular biology and biochemistry.
  • Experience with mammalian cell culture.
  • Excellent communication and troubleshooting skills and the ability to work in a highly collaborative, fast-paced environment.
  • Ability to work independently and within a team.

Preferred Qualifications:

  • Hands-on experience with cell culture is preferred.
  • Experience with basic cell biology assays (flow cytometry, qPCR, western blotting, immunofluorescence/immunohistochemistry)
  • Familiarity with MS Excel and PowerPoint for data analysis and presentations.
  • Independently motivated, detail-oriented, and excellent problem-solving abilities
  • Proactive and collaborative mindset, exhibiting an enthusiastic team attitude.
  • Meticulous record keeping, documentation, and reporting of research.

What We Offer:

  • A cutting-edge scientific team open to mentorship and networking
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc.
  • Participation in regular scientific seminars with industry experts
  • Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.