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Spring 2024 Co-op: Prime Editing Platform

Prime Medicine

Prime Medicine

Cambridge, MA, USA
Posted on Saturday, September 9, 2023

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit

Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Spring 2024 semester with experience in Biology, Chemical Biology, or related subjects to join the Platform Delivery Innovation team. The successful candidate will join a team working to increase the safety and potency of Prime’s viral vectors. In this position, the co-op will support projects designed to minimize viral genome size, maximize potency, and increase control of Prime Editor expression. They will gain experience in molecular biology, genome editing, and viral vector production. The ideal candidate will thrive in a fast-paced, evolving research program and be comfortable in a role supporting a range of therapeutic areas.

Primary Responsibilities:

  • Mammalian cell transfection and analyses including next-generation sequencing
  • Production and purification of AAV vectors using aseptic technique
  • Cloning and production of plasmid DNA using standard molecular biology techniques
  • Maintain thorough electronic records and lab notebooks, and present findings to multi-disciplinary teams in oral and written formats


  • B.S. or M.S. candidate in Biology, Biochemistry, Bioengineering, Chemistry or related major
  • Basic knowledge of molecular biology, cell biology and biochemistry
  • Excellent troubleshooting and communication skills
  • Ability to work independently and within a team in a collaborative environment

Preferred Qualifications:

  • Hands-on experience with transfection or transduction of mammalian cells
  • Experience with basic molecular biology assays (DNA extraction, PCR etc)
  • Conceptual or hands-on experience with design and/or production of viral vectors
  • Highly motivated, detail-oriented, and excellent problem-solving abilities

What We Offer:

  • A cutting-edge scientific team open to mentorship and networking
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc.
  • Participation in regular scientific seminars with industry experts
  • Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.