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Spring 2024 Co-op: mRNA & LNP Process Development

Prime Medicine

Prime Medicine

Cambridge, MA, USA
Posted on Saturday, September 9, 2023

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit

Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Spring 2023 semester to work in a cross-functional LNP formulation and process development team. The candidate will work with formulations scientists, process development engineers, and chemical engineers to optimize mRNA and LNP formulation and processes related to the manufacture of mRNA and LNPs. The candidate will gain hands-on experience with various LNP formulation techniques and processes, analytical and biophysical characterization, and play a critical role in solving challenging problems associated with LNP formulation and process development.

We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.

Primary Responsibilities:

  • Collaborate with the mRNA and LNP formulation and process development team, and cross-functional teams to design and execute experiments supporting Prime Medicine goals
  • Execute experiments to optimize and understand the robustness of LNP formulations and related processes
  • Perform analytical testing for assessing LNP formulations and payload quality as it relates to critical process parameters
  • Effectively communicate results to internal and external meetings, and present final summary to the team
  • Document and manage all experimental planning and progress in electronic lab notebook in an organized manner, providing statistical analysis and troubleshooting where appropriate.
  • Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies


  • Enrolled in B.S./M.S. in Chemical Engineering, Chemistry, Bioengineering or Biochemistry
  • Prior experience with mRNA and LNP formulations and processes of making LNPs, and wet lab is preferred.
  • Knowledge of tangential flow filtration, and characterization techniques (DLS, UV-Vis, HPLC)
  • Familiarity with DOE is a plus
  • Excellent written and verbal communication skills.
  • Curious, ability to work independently or collaboratively as needed
  • Self-motivated, detail-oriented with strong critical thinking skills and excel at identifying and solving problems.

What We Offer:

  • A cutting-edge scientific team open to mentorship and networking
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc.
  • Participation in regular scientific seminars with industry experts
  • Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.