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Spring 2024 Co-op: In-Process Chemistry Analytics

Prime Medicine

Prime Medicine

Data Science
Watertown, MA, USA
Posted on Saturday, September 9, 2023

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit

Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Spring 2024 semester with interest in nucleic acid R&D to join the process chemistry team. The candidate will be involved in day-to-day routine laboratory activities for supporting in-process analytics including UV measurement, UPLC and LC-MS analysis, integration for UPLC chromatograms of various stages in-process guide RNA samples. The candidate will learn a variety of in-process analytics quickly, will generate data and document them in the Benchling, and will share results at scientific team meetings.

We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.

Primary Responsibilities:

  • Supports in-process analytics for Prime’s long guide RNA (ribonucleic acid) platform development using various laboratory techniques (including UPLC, LC-MS, Nano drop, Karl Fisher etc.)
  • Operate UPLC and LC-TOF, ensuring proper calibration, maintenance, and troubleshooting as needed.
  • Execute sample runs and data collection (integration, deconvolution, etc.) in accordance with established protocols and experimental designs in a timely manner.
  • Assist in the development, optimization, and stability of guide RNA by in-process analytical methods.
  • Managing the analytical lab operations, and workflow for sample requests
  • Maintain laboratory cleanliness, organization, and compliance with safety protocols.
  • Documents data in the Benchling, write a project summary report in brief and share results at scientific team meetings.


  • Must be enrolled in the undergraduate/advanced degree program at the time of Co-op program
  • Excellent written and oral communication skills, good organization skills, the ability to multi-tasks, and work as a team player and independently.
  • A passion for learning and contributing to multiple facets of a program.

Preferred Qualifications:

  • Prior relevant internship/Co-op experience.
  • Familiarity with Microsoft Office software.
  • Familiarity working in chemistry laboratory, and experience with instrumentation such as UPLC, LC-MS, Nano drop is a plus.
  • Familiarity about drug substance characterization is a plus.

What We Offer:

  • A cutting-edge scientific team open to mentorship and networking
  • Full reimbursement for monthly commuting costs including subway, commuter rail, parking, Bluebikes, etc.
  • Participation in regular scientific seminars with industry experts
  • Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.