Translational Lead
Owkin
About us
Owkin is an AI biotechnology company that uses AI to find the right treatment for every patient. We combine the best of human and artificial intelligence to answer the research questions shared by biopharma and academic researchers. By closing the translational gap between complex biology and new treatments, we bring new diagnostics and drugs to patients sooner.
Owkin has raised over $300 million and became a unicorn through investments from leading biopharma companies (Sanofi and BMS) and venture funds (Fidelity, GV and BPI, among others).
Owkin is seeking the best and brightest to join our fast-growing and dynamic team.
#LI-RM1
About the role:
The Translational Lead develops the exploratory biomarker strategy for our clinical studies, decides on appropriate methods of analytical implementation and data acquisition and interprets translational biomarker data from our early-phase clinical studies to shape forward looking clinical development. Collaborating with AI/ML data scientists, this pivotal role also ensures our AI-generated mechanistic hypotheses are suitably tested in the clinic generating a virtuous cycle of data flow that cross-informs clinical development and AI engine refinement. The initial clinical focus will be small-molecule immuno-oncology.
In particular, you will:
- Be the translational strategy lead in matrixed cross functional research/clinical teams to devise and advance scientific/medical strategies for key translational milestones across the portfolio in direct clinical development and
- Define and implement translational objectives and endpoints for precision medicine clinical study protocols to achieve rapid proof of concept and clear path to registration in molecularly defined patient populations.
- Direct and oversee outsourcing and validation of clinical biomarker assays.
- Lead the interpretation of data and their presentation in clinical study reports and publications; accountable for the design and execution of exploratory studies in Translational Medicine.
- Articulate and implement a clinical biomarker strategy informed by and suitable to feed back to our AI engines with a goal of informing indication selection, personalized medicine, PK/PD relationships, prognostic and predictive biomarkers, biomarkers of response and resistance to therapy.
- Work collaboratively with the Lead Physician and Head of Clinical Operations to ensure biomarker sample collection and analysis is both medically and operationally feasible.
- Liaise closely with the Preclinical Research Lead to enable smooth bench-to-bedside and back again data flow and hypothesis testing including around rational drug combinations.
- Ensure fit-for-purpose biomarker data is delivered from our clinical studies on-time and on-budget.
- Manage the scientific relationships with the central lab and with third-party vendors of biomarker analytical services.
- Present findings of exploratory analysis to the study team and to Owkin governance with a view to evolving our clinical study design to take advantage of emerging data.
- Grow and develop collaborative scientific relationships both externally and internally.
Position is based in our PARIS or LONDON offices or remotely in the UK or FRANCE.
About you
Required qualifications / experience:
- Life-sciences PhD. Significant bio/pharmaceutical industry experience in drug development, specifically direct experience in translational medicine, in a field directly relevant to oncology
- Solid background in immunology, ideally with focus on immuno-oncology
- Good understanding of CDx development in tissue and/or blood-based patient selection markers
- You are a highly motivated, decisive, and results-oriented individual who is proactive, resourceful, and efficient with the flexibility and creativity to excel in and contribute to a rapidly growing company in a matrixed environment
- Able to work across functions and levels, build relationships and influence decision-making, while managing tight timelines
- In depth knowledge of biomarker-informed clinical trial design and execution.
- Collaborative, inquisitive mindset and proven capacity to implement innovative solutions to improve patients’ lives.
Please submit your CV in English
What we offer
- Flexible work organization and access to remote work
- Friendly and informal working environment
- Opportunity to work with an international team with high technical and scientific backgrounds
Recruitment Process & Security
- Please complete the form and submit your CV.
- Owkin is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, sex, gender, sexual orientation, age, color, religion, national origin, protected veteran status or on the basis of disability.
- Owkin is a great place to work. Unfortunately, being a coveted workplace means we are vulnerable to recruitment phishing scams. We urge all job seekers and candidates to be wary of potential scams. Most of these have individuals posing as representatives of prominent companies, including Owkin, with the aim of obtaining personal, sensitive, or financial information from applicants. These scams prey upon an individual’s desire to obtain a job and can sometimes “feel” like a genuine recruitment process. Some red flags are identified below. Should you encounter a recruitment process that claims to be for Owkin but is not consistent with the below, please do not provide any personal or financial information:
- Legitimate Owkin recruitment processes include communication with candidates through recognized professional networks, such as LinkedIn.
- Communication is always through an official Owkin email address (from the @owkin.com domain), over the phone or though our applicant tracking system (Greenhouse).
- The Owkin talent team do use platforms such as LinkedIn and Job Teaser, however if you have any concern or doubt about this contact, please ask for them to send an email from @Owkin.com.
- The Owkin talent team will not solicit personal data from candidates during the application phase including, but not limited to, date of birth, social security numbers, or bank account information;
- Legitimate Owkin interviews may be conducted over the phone, in person, or via an approved enterprise videoconferencing service (Google Meets). They will not occur via Signal, Telegram or Messenger
- Owkin offers of employment are based on merit and only extended once a candidate has interviewed with members of the talent and hiring team. Offers will be extended both verbally and in written format.
If you think that you have been a victim of fraud,
- Check the identity of the talent team on LinkedIn.
- Check the existence of the position on our website https://owkin.com/hiring
- Notify Owkin's recruitment unit at this address hiring@owkin.com
- contact the following authorities: