Principal Scientist, Viral Vector Development
Orchard Therapeutics
Location: London (Hammersmith)
Reporting to: Director, Viral Vector Development
Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cell (HSC). Orchard has its global headquarters in London and U.S. headquarters in Boston.
Technical Development sits within Technical Operations at Orchard and is responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production processes, which meet patient demand for therapeutic products of the best quality.
Reporting to the Director, Viral Vector Development, the Principal Scientist, Viral Vector Development, will be responsible for the development of innovative, high-yield processes for production of LVVs. The candidate will closely interact with other functional groups including analytics, cell process development, CMC and regulatory teams. This role is based in our Hammersmith, London facilities within our global headquarters and will suit candidates who would like to join a global company with a diverse and dynamic work environment that provides opportunities for sustained personal and professional growth.
Key Elements and Responsibilities
· Design, develop and improve upstream and downstream processes for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development
· Execute experimental plans, analyse experimental data and write technical reports
· Provide hands-on technical expertise/scientific guidance to team members and supervision of junior colleagues
· Contribute to the transfer of improved processes to GMP and assist with oversight of manufacturing activities as required
· Assist in the reporting, investigation and resolution of deviations encountered during GMP production activities
· Prepare, review and complete protocols/SOPs, study reports and assist with regulatory submissions
· Communicate, share and discuss work progress internally and externally
· Perform landscape scouting to drive continuous improvement in quality, yield and COGs
· Provide expert review and approval of executed batch, records, test records and associated documentation for release of LVVs and plasmids used in their production.