Senior Scientist/Principal Scientist, Radiobiology
ARTBIO
Oslo, Norway
Posted on Oct 4, 2024
Summary We are seeking a Senior/Principal Scientist in Radiobiology to join our growing Translational Biology team. We are also open to relocating new colleagues to Oslo! In this role, you will play a key part drug discovery and development to advance our innovative pipeline of targeted radiotherapies designed to revolutionize cancer treatment. Are you a highly motivated scientist with a passion for oncology research? Do you thrive in a collaborative environment and enjoy tackling complex scientific challenges? If so, we encourage you to apply! Responsibilities
- Manage, plan and execute in-vitro radiobiology studies to enable development of ARTBIO novel radioligand candidates from early Discovery to IND-readiness according to the company’s strategy
- Design and execution of radiolabelling and analytical characterisation of radioligands and assessment of quality in close collaboration with the in-vitro radiochemistry team
- Interface with project team and leadership to lead project goals and experimental design for drug development
- Collaborate with external vendors and academic facilities for sourcing of reagents and execution of experimental activities
- Provide mentorship and supervision to other ARTBIO preclinical team members so that experiments and projects are performed according to plan and internal ways of working
- Support writing of regulatory documentation related to pre-clinical studies for RLT candidates selected for clinical development
- Provide deep scientific expertise to guide selection of novel targets, candidate molecules and best experimental approaches to address relevant, scientific questions
- Develop innovative solutions to mitigate research challenges & increase throughput and processes efficiency
- Oversee data collection, analysis, interpretation, reporting and presentation
- Multi-task and collaborate effectively with other scientists and research associates to accomplish goals on tight timelines. Ability to navigate in a start-up environment and adapt in the ‘unknown’
- Maintain compliance with lab documentation to enable collaboration among multinational project teams
- Analyse experimental results, brainstorm and troubleshoot findings thoughtfully and proactively
- Work seamlessly in matrixed environment to ensure technical support across programs
- Phd or equivalent degree in Molecular Biology, Radioligand therapy development, Radiation Biology, or other relevant discipline with a significant laboratory-based skills component
- At least 5 years working in research projects, particularly in drug discovery and in vitro testing of novel radioligands
- Preferred industry experience, preferably radioligand therapy or oncology
- Good English speaking and writing skills
- Critical understanding of the principles of receptor pharmacology theory and experimental methodologies to assess ligand binding
- Specific experience with radioligand therapy development, including radiolabelling and radiopharmaceutical applications
- Proficiency in radiation safety practices and regulations, including working with open sources and radionuclides
- Proven ability to develop, optimize, and validate novel in-vitro methods and techniques and creating and implementing high throughput screening methods to streamline research processes
- Experience with Analytical Techniques such as use of gamma counters, Germanium Detectors, Dose calibrators, Thin Layer Chromatography and High-Performance Liquid Chromatography is a plus
- Conducting and interpreting internalization assays to understand cellular uptake of radioligands.
- Strong analytical skills for processing and interpreting complex experimental data
- Ability to work effectively within interdisciplinary teams and contribute to collaborative research efforts
- Excellent communication skills for writing reports, preparing presentations, and publishing research findings
- Experience managing research projects, timelines, and resources
- Line management experience, including supervising and mentoring junior scientists
- Demonstrated problem-solving abilities and innovation in addressing research challenges
- Focus on the “we” rather than the “me”
- Motivated by patients, passionate about our company culture, inclusive and respectful of all colleagues