About Us:

Arnatar Therapeutics is a clinical stage, mission-driven biotechnology company advancing transformative RNA medicines using best-in-class antisense technology. We combine deep scientific expertise in RNA biology, medicinal chemistry, and translational development to deliver therapies for diseases with high unmet medical need. Our culture prioritizes innovation, scientific rigor, and collaborative problem-solving to accelerate the translation of novel RNA modalities into the clinic.

Position Summary:

Arnatar is seeking a Research Associate Oligonucleotides. This Research level R&D position requires strategic thinking, an ability to work pro-actively and collaboratively. Candidate should have a portfolio mindset and deep scientific expertise. Applicants should have strong experience in oligonucleotide drug synthesis and optimization with a proven track record in delivering clinical results. Working as part of a cross-functional team spanning chemistry, biology, analytical sciences, pharmacology, DMPK, and toxicology, the candidate will manage collaborations and CRO vendors. This candidate must have a “can do” attitude with a hands-on approach, being in the lab.

Key Responsibilities:

• Design, synthesis, purification, and analysis of chemically modified oligonucleotides

• Improve upon and/or develop new synthetic methods and processes to expand the current capabilities

• Utilize analytical instrumentation such as UV-Vis spectroscopy, HPLC, and LC-MS for the analysis of both crude and purified synthetic products

• Effectively troubleshoot synthetic/process issues and independently find solutions

• Improve upon and/or develop new methods and automation for the downstream processing of synthetic oligonucleotides and their subsequent analysis/purification and annealing into siRNA duplexes

• Analyze, interpret, and organize analytical data to present to team members

Required Qualifications:

• Bachelor’s or Master’s degree in Chemistry, Biochemistry, or a related field

• 0-4 years of work experience, preferably in an industrial setting

• Experience in solid-phase synthesis of biomolecules and a good understanding of the procedures involved in SPS are preferred

• Experience with instrumentation such as HPLC, LC-MS, UV-Vis spectrometry, etc. is required. Experience in developing new chromatographic methods (IEX/RP HPLC, SPE, LC-MS) is a plus

• Ability to function within a highly interdisciplinary environment with tight timelines is a must

• Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required

• Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment

Experience in the following areas:

• Solid experience in oligonucleotide synthesis is required

• Bioconjugation Chemistry is preferred

• Cell delivery technologies is a plus

• Understanding of the IP and regulatory landscape around oligonucleotide therapeutics

• High level of creativity and productivity with strong problem-solving skills, synthetic methods, reaction mechanisms analytical methodology

• Exceptional interpersonal skills, ability to build and maintain relationships with colleagues at all levels of the organization

Preferred Qualifications:

• Desire to work with the team in the lab making novel oligos and developing new processes

What we offer:

• Health Benefits

• Industry competitive compensation

• Annual target bonus

• Stock options

• 401K plan

• Career advancement opportunities

• Weekly town halls to share business and scientific updates

We are not sponsoring employment visa’s currently

Arnatar Therapeutics is an EEOC Employer

Notice to agencies: Arnatar Therapeutics will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity.

Pay: $70,000.00 - $80,000.00 per year

Work Location: In person (San Diego)

‍

‍

‍