About Arnatar Therapeutics

Arnatar Therapeutics is a clinical stage, mission-driven biotechnology company advancing transformative RNA medicines using best-in-class antisense technology. We combine deep scientific expertise in RNA biology, medicinal chemistry, and translational development to deliver therapies for diseases with high unmet medical need. Our culture prioritizes innovation, scientific rigor, and collaborative problem-solving to accelerate the translation of novel RNA modalities into the clinic.

Position Summary

Arnatar is seeking a Research Assistant Oligonucleotides. This research level R&D position requires strategic thinking, an ability to work pro-actively and collaboratively, portfolio mindset and deep scientific expertise across several of the following disciplines: Applicants should have strong experience in oligonucleotide drug synthesis and optimization with a proven track record in delivering clinical candidates. Working as part of a cross-functional team spanning chemistry, biology, analytical sciences, pharmacology, DMPK, and toxicology, the candidate will also manage collaborations and CRO resources as needed. This candidate must have a “can do” attitude with a hands-on approach, being in the lab with direct reports and staff. This role is a Chemistry lab role with emphasis on the oligo production in the lab and short timelines.

Role and responsibilities:

• Design, synthesis, purification, and analysis of chemically modified oligonucleotides.
• Improve upon and/or develop new synthetic methods and processes to expand the current capabilities.
• Utilize analytical instrumentation such as UV-Vis spectroscopy, HPLC, and LC-MS for the analysis of both crude and purified synthetic products.
• Effectively troubleshoot synthetic/process issues and independently find solutions.
• Improve upon and/or develop new methods and automation for the downstream processing of synthetic oligonucleotides and their subsequent analysis/purification and annealing into siRNA duplexes.
• Analyze, interpret, and organize analytical data to present to team members.

Required qualifications:

• Bachelor’s or Master’s degree in Chemistry, or a related field.
• 0-4 years of work experience, preferably in an industrial setting.
• Experience in solid-phase synthesis of biomolecules and a good understanding of the procedures involved in SPS are preferred.
• Experience with instrumentation such as HPLC, LC-MS, UV-Vis spectrometry, etc. is required. Experience in developing new chromatographic methods (IEX/RP HPLC, SPE, LC-MS) is a plus.
• Ability to function within a highly interdisciplinary environment is a must.
• Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required.
• Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment.
• Experience in building robust data packages to support IND filings.

Preferred Qualifications:

• Desire to work with the team in the lab making novel oligos and developing new processes.
• Experience interacting with CMOs for GLP tox batch and GMP synthesis.

‍

Notice to agencies: Arnatar Therapeutics will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Arnatar Therapeutics via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Arnatar Therapeutics. No fee will be paid in the event the candidate is hired by Arnatar Therapeutics as a result of the referral or through other means.

Job Type: Full-time

Pay: $70,000.00 - $80,000.00 per year

‍

‍

‍