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Senior Scientist, Analytical Sciences

ABOUT US

Aera Therapeutics was founded with a vision to unlock the potential of genetic medicines across a broad range of modalities and therapeutic areas.

Our novel protein nanoparticle (PNP) delivery platform is based on endogenous human proteins, leveraging the discovery of human proteins derived from retroelements that self-assemble to form capsid-like structures and which can package and transfer nucleic acid cargo. This platform combines the benefits of an endogenous, fully synthetic self-assembling system with the engineerability of a protein-based system and has the potential to enable various genetic medicine modalities.

With a world-renowned scientific founder and a distinguished Board of Directors, Aera has raised $193 million led by Arch Venture Partners, GV, and Lux Capital.

How will your role make an impact at Aera Therapeutics?

Reporting to the Associate Director, Analytical & Bioanalytical Sciences, you will develop analytical methods and characterize novel RNA delivery systems. Applying your expertise in Analytical method development, you will contribute to cross-functional workflows focused on developing the company's novel delivery platform for genetic medicines.

You will:

• Develop analytical and bioanalytical methods for the testing and characterization of nanoparticle delivery systems for mRNA
• Lead chromatographic method development (LC-UV/CAD and LC/MS) for the quantitation of proteins (Fabs,mAbs), Lipids, mRNA, small RNAs, lipids for supporting development of nanoparticulate delivery systems
• Generate novel method development strategies and implementation of novel analytical methods
• Evaluate orthogonal methods such capillary electrophoresis, plate based colorimetric and fluorescence quantitation and characterization of above-mentioned analytes
• Collaborate with cross-functional teams to support project goals and timelines
• Prepare, evaluate, and present data to internal audiences
• Review and approve analytical results, protocols and reports
• Participate, review and approve analytical investigations
• Stay current with scientific literature and emerging trends in analytical and related fields.

Qualifications:

• Ph.D. (with 5+ years ) or M.S. degree (with 8+ years ) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or related field with a background in analytical method development
• Experience in development of analytical methods of large molecules (protein/mRNA) and analytical characterization of lipid nanoparticle is required.
• Expertise in several analytical techniques such as H/UPLC (SEC, RP, HILIC, IEX), LC/MS, electrophoresis (CE-SDS, icIEF), plate-based methods (colorimetric/fluorometric) and ELISAs.
• Experience working with Agilent/Waters/Thermo U/HPLC systems with is required
• Experience in early to late-stage drug development
• Ability to work onsite at Aera office 5 days a week

Benefits

• Healthcare
• 401K
• Flexible PTO
• Commuting subsidy
• Parental leave

Aera Therapeutics is committed to providing equal employment opportunities by recruiting, hiring, training and promoting applicants and employees without regard to race, color, religion, creed, national origin, sex, age, ancestry, sexual orientation, genetics, pregnancy, marital status, familial status, victim of domestic violence status, gender identity/expression, disability, handicap, military obligations, veteran status or any other category protected by federal, state or local laws.

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