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Research Associate II, Therapeutic Discovery

Cambridge, MA

ABOUT US

Aera Therapeutics was founded with a vision to unlock the potential of genetic medicines across a broad range of modalities and therapeutic areas.

Our novel protein nanoparticle (PNP) delivery platform is based on endogenous human proteins, leveraging the discovery of human proteins derived from retroelements that self-assemble to form capsid-like structures and which can package and transfer nucleic acid cargo. This platform combines the benefits of an endogenous, fully synthetic self-assembling system with the engineerability of a protein-based system and has the potential to enable various genetic medicine modalities.

With a world-renowned scientific founder and a distinguished Board of Directors, Aera has raised $193 million led by Arch Venture Partners, GV, and Lux Capital.

How will your role make an impact at Aera Therapeutics?

Aera Therapeutics is looking for a Research Associate II to support our drug discovery platform from early drug discovery through translational research. Your role will support Aera’s therapeutic discovery research aiming to develop a new generation of genetic medicine. You will be asked to work together with teams including Delivery Technologies, Formulation, and In Vivo Operations. You will report into our Senior Scientist I, Therapeutic Discovery and you will be onsite 5x a week in our Cambridge office.

You will:

• Isolate, culture, and manipulate primary immune cells, maintain immortalized cell lines.
• Design, run, and analyze flow cytometry experiments.
• Participate to the development of novel cell-based assays for evaluating immune cell function.
• Run in vivo experiments, from tissue processing to data analysis.
• Maintain accurate and comprehensive records of experimental data within the laboratory information management system, ensuring data integrity and accessibility.
• Perform study preparation and organizational activities.
• Present data summaries to a diverse audience.

Qualifications:

• B.S. degree in Immunology (or related Biology field) with 3+ years, or M.S. with 1+ years of industry or academic experience.
• Proficiency in aseptic cell culture methods, from immortalized cell line maintenances to primary human immune cell isolation and culturing.
• Proficiency in acquiring, analyzing, and interpreting 5+ parameters flow cytometry data.
• Experience running functional assays with engineered immune cells, including but not restricted to proliferation assays, cytokine readouts (e.g., ELISA), in vitro cytotoxicity assays (e.g., Incucyte).
• Experience with animal work, including tissue processing (e.g., blood, lymphoid tissues) and flow cytometry analysis
• Collaborative mindset and ability to work in a cross-functional team.
• Demonstrate organizational abilities, adept critical thinking, reliability, and commitment to the team’s success.
• Display desire and capacity to acquire new techniques and contribute to projects.
• Proficiency in Microsoft Office applications and software such as GraphPad Prism and FlowJo.

Benefits

• Healthcare
• 401K
• Flexible PTO
• Commuting subsidy
• Parental leave

Aera Therapeutics is committed to providing equal employment opportunities by recruiting, hiring, training and promoting applicants and employees without regard to race, color, religion, creed, national origin, sex, age, ancestry, sexual orientation, genetics, pregnancy, marital status, familial status, victim of domestic violence status, gender identity/expression, disability, handicap, military obligations, veteran status or any other category protected by federal, state or local laws.

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