Senior Medical Director, Translational Medicine
The successful candidate will be a strategically minded, hands-on early clinical development expert with the responsibility for overseeing the transition of projects from research into clinical development, and for the strategy for early clinical development of novel therapies for rare diseases. Success depends on the integrity, knowledge, imagination, creativity, skill, diversity and teamwork focus of the candidate. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. The individual will collaborate with talented and dedicated colleagues across R&D. This position will be a critical element in Vertex’s approach to create an effective bridge between discovery research and clinical development.
The Senior Director will:
Work closely with other functional experts across the organization
Provide medical leadership and translational medicine expertise on cross-functional Project Teams
Develop early clinical development plans that are innovative, safe and create a foundation for decision making
Be responsible for the medical aspects of Phase I studies throughout development, including development of innovative clinical biomarkers to support decision making
Provide clinical and translational leadership to drive the design and interpretation of Phase 1-2a studies, in close collaboration with experts in Clinical Biomarkers, Clinical Pharmacology, Modeling & Simulation, and Clinical Operations
Work with teams to ensure effective execution of Phase 1-2a studies within the portfolio
Responsible in collaboration with Global Patient Safety for safety evaluation in early development programs
Support exploratory biomarker efforts in collaboration with Clinical Biomarkers and Research groups to aid in clinical and project decision making
Provide clear and timely communication and interpretation of study results to department and organizational governance, functional area experts and development review committees
Engage with external academic and industry partners in planning and executing strategy and clinical studies
Engage with external scientific and medical experts to bring insight to development programs
Work with colleagues across the research and clinical organizations to foster an end-to-end view of drug development, with a focus on improving patient care
MD or MD/PhD
Board certified or eligible in a medical or pediatric subspecialty preferred
Strong record of basic and/or translational research productivity
Early clinical development experience in an industry setting
Experience with design, execution, and analysis of Phase 1-2a clinical studies
Effective at building alliances across functions, based on end-to-end drug development thinking and experience
Excellent interpersonal communication skills, able to drive collaborations across a matrixed organization
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.